Genistein treatment (20 and 80 μg/kg) on heme oxygenase-1 (HO-1) expression in PAH induced by monocrotaline (MCT) in rats as dose dependently improved the RV hypertrophy index, increased the expression of HO-1, and decreased the elevated mean PA pressure [67]. The gene discussed is HMOX1; the disease is pulmonary arterial hypertension.