In the clinical study of Tian QH et al. [168], METTL1 downregulated the tumor suppressor gene PTEN. Moreover, mainly within the integrated analysis and predictive models, METTL1, in combination with aberrant expression of other m7G regulators and various m7G-related RNAs, is correlated with poor prognosis of cancer patients [162, 168–172]. Here, METTL1 is linked to cancer.