To gain insight into the influence of AMPK phosphorylation level on the effects of CHNQD-0803, we treated non-small cell lung carcinoma H1299 cells (with normal expression level of LKB1) and A549 cells (LKB1 deficiency) (Supplementary Fig. S1C) with CHNQD-0803. Here, STK11 is linked to non-small cell lung carcinoma.