The association between KS and a scleroderma is unclear, we suggest that since in KS both fibroblasts and endothelial cells are infected by HHV8, inducing the production of pro‐angiogenic and inflammatory cytokines,7 it could lead to cellular dysfunction and the overproduction of Transforming Growth Factor Beta and Vascular Endothelial Growth Factor that stimulate the fibroblasts to synthesis excess of collagen and fibrosis as it occurs in systemic scleroderma.8 Here, VEGFA is linked to scleroderma.