ADORA3 and asthma: Mediation is controlled through adenosine receptors like ADORA3. Previously, studies have shown that while single nucleotide polymorphisms (SNPs) of ADORA3 loci are not associated with asthma (15, 16), ADORA3 expression is associated with immunoglobulin E levels in whole blood samples of asthmatic patients (17) and is differentially expressed when comparing patients with severe asthma to controls (18).