PDGFB and glioblastoma: The authors further found that these finding are due to different signaling of TAM survival by different subtypes of GBM: PDGFB-driven GBM induced activation of TAMs while mesenchymal RAS-driven GBM signal TAM survival through inflammation and angiogenic signaling, with RAS-driven GBM effectively targeted through the combination anti-TAM and angiogenesis (97).