HIF1A and myopia: This relationship has also been described in genetic analyses revealing a moderate involvement of the Hif-1α signaling pathway in myopia (98, 100), However, tree shrews induced with myopia do not exhibit changes in scleral Hif-1α mRNA expression (101, 102), and guinea pigs with induced myopia show reduced scleral Hif-1α mRNA, highlighting the need for additional work in this field (102).