In fact, more and more experts suggest antiviral treatment for chronic hepatitis B patients with low-level HBV DNA replication if they are accompanied by one of the following risk factors, regardless of whether the patient’s ALT is abnormal (9): patients over 30 years old, patients with cirrhosis or liver cancer in the family, patients with apparent inflammation (G ≥ 2) or fibrosis (F ≥ 2) in the liver indicated by non-invasive indicators or liver histological examination, or extrahepatic manifestations related to HBV infection. The gene discussed is GPT; the disease is Cirrhosis.