ADAR and cancer: While murine and human ADAR1 share a high degree of homology in both sequence and function, mice encode only a single Apobec3 protein which does not have high homology to human APOBEC3A and APOBEC3B, the two of the seven APOBEC3 enzymes in human associated with cancer (Durfee et al., bioRxiv 2023.02.24.529970).