An example of a non-canonical MHC-bound peptide from a cancer-relevant gene is an 11 aa-long MHC bound peptide (binding affinity 8.91 nM) from a downstream ncORF in TMED3, an upregulated gene in breast cancer promoting proliferation, migration, and invasion of breast cancer cells (47) (Figure 3C). Here, TMED3 is linked to cancer.