Even a small subset of biomarkers may contain sufficient signal to reconstruct a much larger subset of biomarkers: for instance, some biomarkers regularly co-express with other biomarkers (e.g. CD20 and CD21 in B cells), while others can be inferred from the cell's morphology (e.g. the nucleus and cytokeratin expression of a proliferating tumor cell may indicate Ki67 expression). This evidence concerns the gene MKI67 and neoplasm.