Lio et al. loaded siRNAs targeting TGFβR-1 into the mesopores of polylysine-modified (PLL) MSNPs to construct MSNPs-PLL complexes, and as the result, transdermal delivery of siRNA to cutaneous squamous cell carcinoma in xenograft model mice significantly down-regulated the expression of TGFβR-1 and inhibited tumor growth by as much as 2-fold [83]. Here, TGFBR1 is linked to cutaneous squamous cell carcinoma.