The radiation-induced changes in ACE and ACE2 expression are similar to findings in a hypertension rat model, where male rats were observed to have an imbalance in the relative levels of lung ACE and ACE2 levels pathways favoring activation of the proinflammatory ACE/AngII signaling pathway (Martins et al., 2021). The gene discussed is ACE2; the disease is Hypertension.