Ultimately, the discovery of new host ligands of non-excessively studied surface proteins such as the plasmin-sensitive surface protein (Pls), an MRSA-specific cell envelope-displayed glycoprotein (Savolainen et al., 2001; Josefsson et al., 2005; Bleiziffer et al., 2017), may also aid in the design of additional anti-infective strategies and further fuels our knowledge of staphylococcal infection dynamics. The gene discussed is ART4; the disease is staphylococcal infection.