In addition, and considering synaptic alterations described in cultured mouse neurons,8 we carried out co-localization analysis of Bassoon (presynaptic marker) and PSD-95 (postsynaptic marker) to quantify number of synapses, however, we did not detect any difference between Control- and FTD-iNs (Fig. 2D). Here, DLG4 is linked to frontotemporal dementia.