CHMP2B and frontotemporal dementia: In the case of CHMP2B-FTD, iPSC lines were recently generated from fibroblasts of three FTD patients, and isogenic controls were obtained using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9) genome editing to correct the causative mutation.14 These iPSCs were differentiated into forebrain cortical neurons that presented enlarged endosomes and abnormal mitochondria leading to increased oxidative stress together with an imbalance of iron homeostasis.