At least one of the following:• C-Reactive Protein (CRP) >5 mg/L• Procalcitonin >0.15 ng/ml• Ferritin >300 mcg/L• Fibrinogen >400 mg/dl• D-Dimer >560 ng/ml• Neutrophils >7,500 cells/mcl• Lymphopenia: <2 years: <4,000, 2–3 years: <3,000, >4 years: <1,500 cells/mcl• Albumin <3 g/dl. Here, ALB is linked to lymphopenia.