Based on the relationship between activation of AMPK signaling pathway and autophagy in previous studies, combined with the results of KEGG enrichment analysis of the intersection genes of DLL3 that affect the prognosis of COAD in the database, we found that the intersection genes are involved in the pathway with both AMPK signaling pathway, mitophagy-animal, and other tumor-related and immune-related pathways. Here, DLL3 is linked to neoplasm.