The deficiency of coagulation factors, including fibrinogen or Factor I (FI), prothrombin or FII, FV, FVII, FVIII, FIX, FX, FXI, and FXIII, and combined factor deficiencies such as FV and FVIII are considered as rare bleeding disorders (RBDs) [2]. This evidence concerns the gene F8 and hemorrhagic disease.