Recent studies on the pathogenesis of APS and clinical trials have shown that antiphospholipid antibodies exist outside some classification criteria and are associated with thrombotic events and morbid pregnancy events, including (1) Anti-prothrombin antibodies (47) (2); Anti-β2GPI domain1antibodies (48) (3); IgA anti-β 2GPI antibody and IgA anticardiolipin antibody (49) (4); Anti-cardiolipin/vimentin antibodies (50) (5); Anti-annexin A2 antibodies/anti-annexin A5 antibodies (51) (6); Antiphospholipid antigen antibody (52) (7); Anti-protein C/protein S antibody (53). This evidence concerns the gene ANXA5 and autoimmune polyendocrinopathy.