1. Positivity for LA, aCL or aβ2GPI only detected once2. Low positive IgG/IgM aCL or aβ2GPI titers3. Persistent positivity for non-criteria aPL, including IgA-aCL and aβ2GPI4. Resistance to Annexin A5 anticoagulant activity5. Thrombocytopenia. The gene discussed is CD79A; the disease is Thrombocytopenia.