Moreover, IFN-γ-expressing CD4+ T cells were enriched in NASH, and methionine/choline deficient (MCD) diet feeding induced milder steatohepatitis and decreased inflammatory macrophage infiltration in mice deficient in IFN-γ compared to the control mice (37, 38). The gene discussed is IFNG; the disease is metabolic dysfunction-associated steatohepatitis.