GNAS and Fabry disease: Studies in transgenic mice in which the activating mutation p.Q227L of Gsα, functionally similar to the R201C/H mutations that cause FD/MAS, was targeted at the central nervous system (Gsα * Q227L) showed that Gsα* mice exhibit a neurobehavioral phenotypes including short- and long-term memory deficits and impaired spatial and associative learning (72, 73).