TNF and inflammatory bowel disease: Inflammatory bowel disease (IBD) is a progressive chronic inflammatory diseasesubdivided into two main subtypes, Crohn’s disease (CD) and ulcerative colitis (UC).Treatment aims to induce and maintain remission to prevent disease progression,including hospitalizations, surgery and worsening of health-related quality of life(HRQoL).1,2In patients with failure or intolerance to conventional treatment, anti-tumournecrosis factor (anti-TNF) agents have become the mainstay of treatment.