Since, the 3’ UTRs of MYC and MYCN harbor let-7 binding sites, repression of let-7 results in higher expression of MYC and MYCN. Thus, the genetic loss of LIN28B in MYCN-driven neuroblastoma results in loss of metastatic potential both in vitro using MYCN-amplified neuroblastoma cell lines and/or PDX samples and in vivo using immunocompromised mice (33). The gene discussed is MYC; the disease is neuroblastoma.