Interestingly, they also observed distant metastasis in the transgenic fish overexpressing both MYCN and LMO1. This observation was supported by the increase in expression of panel of genes involved in tumor cell-extracellular matrix interactions like LOXL3 and integrins - ITGA2B, ITGA3, and ITGA5 (15, 50). This evidence concerns the gene MYCN and neoplasm.