PHOX2B and neuroblastoma: The most frequently harbored alterations of specific genes in neuroblastoma include heritable mutations in the ALK (6) and PHOX2B (8) observed in familial neuroblastoma, chromatin remodeling genes like ATRX (6), ARID1A and ARID1B (9) and other important genes like PTPN11, MYCN, and NRAS (6).