Eosinophilia is a predominant clinical component in lHES, characterized by marked overproduction of eosinophil factor(s) by dysregulated CD3-CD4+ T cells, which are clonal in most cases (63), and in episodic angioedema with eosinophilia (Gleich syndrome), which is a multilineage cell cycle disorder (104). The gene discussed is CD4; the disease is Increased total eosinophil count.