Nevertheless, the expression of CDH1, CCNB1, MCM5 and MAD2L1 markedly up-regulated in BLCA tissues compared with normal tissues, and that of ACTA2, FLNA, TAGLN and TPM1 was significantly down-regulated (P<0.05 for all, Figure 3). This evidence concerns the gene MAD2L1 and bladder transitional cell carcinoma.