Because previous studies have focused on si ngle-gene analyses in various cancer types, we constructed a 10-gene signature (SEPT3, RECQL, PEG10, HPDL, ARL9, LY6D, SCNN1A, RGS5, MTRNR2L12 and TSPAN1) with prognostic significance for TNBC depending on survival-related DEGs in the present study. This evidence concerns the gene SEPTIN3 and cancer.