TGFB1 and neoplasm: IL12 is a stimulatory cytokine that enhances CD8+ T cell function, increases secretion of IFN-γ, improves cytotoxic capacity, reactivates anergic tumor-infiltrating lymphocytes, inhibits Treg-mediated suppression of effector T cells, recruits NK cells to the tumor site, and inhibits IL-10 and TGF-β secretion, all of which suggests that IL12 could modulate the inhibitory microenvironment of solid tumors (55).