CTSZ and breast cancer: Comparing to the highest methylation level (Q4), CTSZ_CpG_1, CTSZ_CpG_3, CTSZ_CpG_5 CTSZ_CpG_6 and CTSZ_CpG_7,8 showed significant association between hypomethylation of CTSZ and BC compared to controls with the highest OR for Q1 of CTSZ_CpG_5 (OR:1.646, P=0.013, Table 3).