When adjusted for age and experimental batches, there was a significant association between hypomethylation of CTSZ and BC cases compared to controls for per 10% reduction of CTSZ_CpG_1 (OR:1.20; P=0.003); CTSZ_CpG_5 (OR:1.39; P=0.004); CTSZ_CpG_7,8 (OR:1.35; P=0.005) in Table 6. The gene discussed is CTSZ; the disease is breast cancer.