RORA and central nervous system cancer: It promotes the upregulation of miR-21 and miR-10a expression in GDEs, leading to MDSC activation via Rora/IκBα/NF-κB and Pten/PI3K/AKT pathways that are involved in glioma progression (32) One study showed that PI3K inhibition had the most substantial effects on global signaling pathways implicated in glioma expansion, reducing tumor cell proliferation (33).