The authors also showed that GL261-bearing mice deficient in miR-15a/16 had lower expression of PD1, TIM3 and LAG3 and displayed higher production of IFNγ, IL2 and TNFα, which relieved the immunosuppressive state of CD8+ T cells, reduced the tumor volume and prolonged mice survival (44). The gene discussed is CD8A; the disease is neoplasm.