MAPK3 and gallbladder cancer: In addition, the results of western blot showed that the phosphorylation levels of AKT (Ser473), GSK-3 β (Ser9), and ERK1/2 (Thr202/Tyr204) decreased in gallbladder cancer cells after CEP55 knockdown, but the protein expression level of FOXO3a increased in the siCEP55 group (Figure 8B).