Under dominant mode, the protective effects of LEP gene rs7799039 GG plus GA genotypes and LEPR gene rs1137100 AA plus AG genotypes on breast cancer risk dwindled, and the risk conferred by ADIPOQ gene rs1501299 TT plus TG genotypes was enhanced, with OR of 1.41 (95% CI: 1.06 to 1.88). Here, LEPR is linked to breast cancer.