In the current study, the primary patient cohort was obtained from the SEER database, employing site codes C18.0-18.9.such as tumor budding, microsatellite status, and genetic mutations (PLAC1, TP53, and KRAS), which were not registered in the SEER database, could potentially impact the accuracy of the nomogram in predicting colon cancer patient survival. The gene discussed is PLAC1; the disease is malignant colon neoplasm.