(133) demonstrated the diagnostic value of serum Exo-miR-34a for the early diagnosis of HCC and the diagnostic potential of the combination of Exo-miR-34a and AFP for diagnosis (AUC= 0.855, sensitivity = 68.3%, specificity = 93.3%) were higher than those of the diagnosis alone and could distinguish between healthy people and HCC patients. The gene discussed is AFP; the disease is hepatocellular carcinoma.