Intravenously infusing CPG2 linked to a F(ab)2 fragment of mouse anti-CEA antibody (3000 U/m2) led to a median CPG2 level in tumors of 0.010 U/g (0–0.208) on prodrug day (2–9 day), the median serum level was 0.037 U/mL (0.011–0.180), and the median level ratio of tumor to blood was 0.4 (0–10.4) (3). The gene discussed is SYNE1; the disease is neoplasm.