Based on the above, a number of studies have confirmed that ubiquitination associated high NCF1 expression in melanoma is closely associated with its metastasis, the role of HCLS1, CORO1A and CCRL2 in melanoma have not been fully elucidated, therefore we selected HCLS1, CORO1A and CCRL2 to investigate the malignant biological behavior in SKCM. Here, HCLS1 is linked to melanoma.