The results of the CPTAC dataset indicated that the protein expression level of PTGES3 was significantly higher in tumor tissues than in normal tissues in COAD, BRCA, KIRC, OV, UCEC, LUSC, LIHC, and HNSC, but downregulated in GBM and no significance in PAAD (Figure 1C). Here, PTGES3 is linked to pancreatic adenocarcinoma.