Recent studies (Fang et al., 2019; Morton et al., 2021; Pradeepkiran et al., 2022) from animal and cell models of AD and sporadic late-onset AD showed that impaired mitophagy triggered Aβ and tau protein accumulation by increasing oxidative damage and cell energy deficiency, leading to synaptic dysfunction and cognitive impairment. The gene discussed is MAPT; the disease is Alzheimer disease.