The protein, which is also an antigen of anti-mitochondrial antibody, accepts the acetyl group formed by oxidative decarboxylation of pyruvate and transfers it to coenzyme A. It has been reported that DLAT is the key mediator of cell survival in chronic myeloid leukemia after tyrosine kinase inhibitor-mediated BCR-ABL1 inhibition (Bencomo-Alvarez et al., 2019). This evidence concerns the gene DLAT and chronic myelogenous leukemia, BCR-ABL1 positive.