Since 2003 (Koldamova et al., 2003), the importance of Nuclear Receptor’s Liver X Receptors/Retinoid X receptors/ABCA1-APOA-I/APOE (LXR/RXR-ABCA1-APOA-I/APOE) regulatory axis for normal/physiological function of APOE, and its relevance to AD pathogenesis in particular, has been demonstrated in tens of studies [for comprehensive reviews see Fitz et al. (2019), Koldamova and Lefterov (2007), Pahnke et al. (2021), Wolfe et al. (2018a), and Kim et al. (2009)]. The gene discussed is APOA1; the disease is Alzheimer disease.