Interestingly, using the same AD mouse model at 8 months of age, Jay et al. showed an increase in 6e10 staining in the cortex and no changes in the hippocampus of Trem2 deficient mice when compared to controls (Jay et al., 2017a) and concluded that in the early stages of amyloid deposition (2-month cortex, 4-month hippocampus) Trem2 deficiency reduces both plaque number and size and at later stages of the disease Trem2 deficiency increases plaque size and area. Here, TREM2 is linked to Alzheimer disease.