Nevertheless, in the last 2 years, several reviews and research papers have been published pointing to aspects of APOE biology that might be worth considering in terms of deciphering the role of APOE as a risk factor of AD and even designing new therapeutic strategies (Parhizkar et al., 2019; Chen and Holtzman, 2022; Li et al., 2022; Lindner et al., 2022; Martens et al., 2022; Raulin et al., 2022). This evidence concerns the gene APOE and Alzheimer disease.