TREM2 and Alzheimer disease: TREM2 expression is increased with the progression of neurodegeneration in AD patients (Perez et al., 2017) and mouse models of AD (Keren-Shaul et al., 2017; Krasemann et al., 2017) – traumatic brain injury (Castranio et al., 2017; Saber et al., 2017), Amyotrophic lateral sclerosis (Jerico et al., 2023), Parkinson’s disease (Liu et al., 2016), and post-stroke remodeling (Song et al., 2022).