This impairment in protein synthesis is caused by sequestration of tRNAGly by mutant GlyRS, with overexpression of tRNAGly rescuing peripheral neuropathy in multiple Drosophila and mouse CMT2D models (Zuko et al., 2021). Here, GARS1 is linked to Autosomal dominant Charcot-Marie-Tooth disease type 2D.