In vitro, wildtype TyrRS is located in granular structures concentrated within the outgrowing axon terminals of differentiating mouse N2a and human SH-SY5Y neuroblastoma cell lines, whereas mutant (p.Gly41Arg and p.Glu196Lys) TyrRS shows a homogenous, non-granular distribution pattern (Jordanova et al., 2006). This evidence concerns the gene YARS2 and neuroblastoma.