YARS1 and neuropathy: Ubiquitous expression of a non-pathogenic TyrRS variant (p.Lys256Asp) in Drosophila does not produce an abnormal phenotype, whereas expression of neuropathy-linked TyrRS variants in Drosophila cause dose-dependent toxicity, with strong ubiquitous expression of DI-CMTC variants leading to developmental lethality (Storkebaum et al., 2009; Leitão-Gonçalves et al., 2012).