AARS1 and peripheral neuropathy: Furthermore, mice homozygous for editing-defective AlaRS alleles exhibit ataxia due to loss of cerebellar Purkinje neurons, but do not develop a neuropathy phenotype (Lee et al., 2006; Stum et al., 2011), suggesting that tRNA mischarging is not the underlying cause of peripheral neuropathies associated with dominant ARS mutations.