Dominant mutations in HARS1, the gene encoding the cytosolic histidyl-tRNA synthetase (HisRS), have predominantly been associated with Charcot-Marie-Tooth disease type 2W (CMT2W) and hereditary motor neuropathy (HMN), with both disease presentations sometimes occurring within the same family (Safka Brozkova et al., 2015). The gene discussed is HARS1; the disease is autosomal dominant Charcot-Marie-Tooth disease type 2W.