YARS2 and Leber hereditary optic neuropathy: While biallelic YARS2 mutations have not yet been reported to cause vision impairments, mutations in YARS2 have been found to interact with mutations in a mitochondrial gene linked to Leber’s hereditary optic neuropathy, worsening cellular respiration in patient cells, and exacerbating associated visual impairments (Jiang et al., 2016).