In addition, Syrbe et al. described the clinical phenotype of eight children with anti-CASPR2-Ab-related AE, including a combination of central symptoms such as encephalopathy, neuropsychiatric symptoms, and insomnia; autonomic symptoms such as hypertension (8/8), weight loss (6/8), sweating (6/8), arrhythmias (5/8), and gut symptoms (2/8). This evidence concerns the gene CNTNAP2 and Hypertension.