Currently, the prevalence of AE is 10–20% in encephalitis cases (Dutra et al., 2018; Hermetter et al., 2018); anti-N-methyl-D-aspartate receptor (NMDAR)-antibody (Ab)-related encephalitis is the most common, followed by anti-leucine-rich glial inactive protein 1 (LGI1), anti-γ-Gammaaminobutyric acid type B receptor (GABABR) and anti-contactin-associated protein-like2 (CASPR2)-Ab-related encephalitis. Here, CNTNAP2 is linked to viral encephalitis.