The immune response to Mtb is characterized by a massive influx of immune cells in an attempt to control infection, primarily macrophages and CD4+ T cells, followed by an overwhelming production of cytokines and chemokines, namely tumor necrosis factor (TNF) and interferon-gamma (IFNγ) (Ernst, 2012; O'Garra et al., 2013; de Martino et al., 2019). The gene discussed is IFNG; the disease is infection.