Those findings mainly focused on depression and PTSD, reporting that FKBP5 variations are also associated with psychiatric-related phenotypes, including post-traumatic pain severity (Bortsov et al., 2013), and with recurrence of depressive episodes and response to antidepressant treatment (Binder et al., 2004), which has been widely observed and validated in patients across different races (Binder, 2009; Zannas and Binder, 2014; Matosin et al., 2018). This evidence concerns the gene FKBP5 and depressive disorder.