SOD1 and amyotrophic lateral sclerosis: Thus, the design of Drosophila ALS models using the combination of the two binaries, LexA-LexOp with UAS-Gal4, may allow for the expression of SOD1 mutations in a specific tissue, for example motor neurons, and the concomitant manipulation of glia, using the UAS-Gal4 where many lines are available at stock centers.