wt SOD1 was found in a complex with Atg9/Beclin1 to control P62/SQSTM1 expression, indeed mice mutant for SOD1-ALS show reduced Atg9/Beclin1 and increased level of P62/SQSTM1 and of ubiquitinated proteins (Nassif et al., 2014). Here, SQSTM1 is linked to amyotrophic lateral sclerosis.