SQSTM1 and spinocerebellar ataxia type 2: In addition, it was shown that cordycepin, a drug that activates AMPK and autophagy, reduces the abnormal accumulation of p62/SQSTM1 and of LC3 observed in cells form SCA2 patients, indicating a dysfunction in the autophagic flux in the disease (Marcelo et al., 2021).