Work in Drosophila as well as in C. elegans, identified a role for lethal(2) malignant brain tumor (L3MBTL1) a histone methyl-lysine protein, and SET domain-containing protein-8 (SETD8) in the control protein misfolding and degradation as their reduction alleviate the phenotypes induced by SOD1. The gene discussed is KMT5A; the disease is brain cancer.