PRKN and Parkinsonism: Many proteins have been identified that may affect parkin/Pink1 modulation of mitophagy: Fbxo7, whose gene PARK15 is mutated in early-onset autosomal recessive forms of Parkinson, directly interacts with parkin to control its translocation to the mitochondrial membrane and functionally interacts with Pink1 to regulate parkin-dependent mitophagy (Burchell et al., 2013).