In the presence of specific mutations or during aging, Tau becomes hyperphosphorylated and changes its structure, decreases its ability to bind microtubules, leading to the formation of insoluble filaments that accumulate as neurofibrillary tangles resulting in tauopathies, a hallmark of AD (Goedert et al., 2017; Hernandez et al., 2022). Here, MAPT is linked to Alzheimer disease.