Using flies, it was also demonstrated how the reduction of the human orthologue of Mask (ANKHD1), a scaffolding protein that inhibits mitophagy, rescues parkin/PINK1 mutant defects, suggesting that the human ANKHD1 might represent an interesting novel therapeutic target for treating PD associated to parkin/Pink1 mutations (Zhu et al., 2015). Here, PRKN is linked to Parkinson disease.