Interestingly, most of the genes associated with PD, such as Parkin, PINK1, and LRRK2, control mitochondria activity and are involved in autophagy-mediated degradation/ubiquitination of proteins to control the turnover of damaged mitochondria (mitophagy; Winklhofer, 2014; Rahman and Morrison, 2019). The gene discussed is PRKN; the disease is Parkinson disease.