Furthermore, transcriptomic analysis using a Drosophila model of mutant PrP revealed a perturbation in cell cycle genes, regulator of protein synthesis and mitochondrial function, revealing data very similar to those in mammalian hosts undergoing to prion disease, further supporting the idea that flies are a well-established animal model to study mammalian prion biology (Thackray et al., 2020). This evidence concerns the gene PRNP and prion disease.