APP and Alzheimer disease: Moreover, it was recently shown that ectopic APP expression is sufficient to trigger aberrant autophagy through its interaction with the carboxyl-terminus of Hsc70-interacting protein (CHIP), a U-box type chaperone associated E3 ubiquitin ligase via transcriptional upregulation of BACE1 and PSEN inducing an AD-like neurodegeneration (Zhuang et al., 2020).