Inducible ablation of mTOR in adult cardiomyocytes (by tamoxifen induction of adult α-MHC-MerCreMer/Mtorfl/fl mice) also led to fatal dilated cardiomyopathy, thus suggesting the functional significance of mTOR in the maintenance of cardiac physiology and homeostasis[174]. The gene discussed is MTOR; the disease is dilated cardiomyopathy.