Homozygous LmnaG609G/G609G mice express lamin A, lamin C, and progerin (a truncated form of prelamin A) with the same protein expression pattern of patients with Hutchinson-Gilford progeria syndrome (HGPS), and exhibit metabolic abnormalities, cardiac electrical alterations and HFpEF, similar to the normally aged mice[156,157]. This evidence concerns the gene LMNA and Hutchinson-Gilford progeria syndrome.