MMP2 and pancreatic neoplasm: Guo et al. reported the predominant expression of beta-2-AR compared to beta-1-AR in the human pancreatic cancer cell lines Miapaca-2 and Bxpc-3 and observed that the neuroendocrine system increased the expression of MMP-2, MMP-9, and VEGF-A due to neuroendocrine activation.