CD8A and chronic obstructive pulmonary disease: Zhen et al. (2018) confirmed in the systematic evaluation and meta-analysis of TCM tonalizing kidney therapy (Bu shen) in the treatment of stable chronic obstructive pulmonary disease that tonalizing kidney therapy can increase lung capacity and reduce the number of CD4+ and CD8+ lymphocytes in patients with stable chronic obstructive pulmonary disease. Huang et al. (2022) found that the TCM combined with Western medicine (WM) can effectively treat the symptoms related to COPD, the treatment efficiency is significantly improved compared with traditional WM.