Therefore, the network analysis suggested that ECXB formula may play a therapeutic role in COPD treatment by regulating signaling pathways, including the TNF signaling pathway, cAMP signaling pathway, VEGF signaling pathway, Hepatitis B Pathways, and Hepatitis C Pathways, suggesting that these pathways may mediate the treatment of COPD. This evidence concerns the gene TNF and chronic obstructive pulmonary disease.