PTGS2 and Hyperglycemia: COX-2 levels are increased in experimental cataracts (Cao et al., 2018), and levels are increased by known cataractogenic stimuli such as hyperglycemia (Song et al., 2020), UV light (Chan et al., 2015), smoking (Huang and Chen, 2011), low glutathione levels, and oxidative stress (Robert and Harding, 1992).