Although the physiological functions of ANO1 are diverse and include secretion of chloride ions and the development of cancer (Hwang et al., 2009; Cho et al., 2012; Huang et al., 2012; Ji et al., 2019), the inhibition of the function of ANO1 channel and reduction of its protein expression has therapeutic effects in head and neck cancers, and in prostate cancers (Ayoub et al., 2010; Liu et al., 2012a; Duvvuri et al., 2012). The gene discussed is ANO1; the disease is head and neck cancer.